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Patients were randomly assigned to undergo wide excision with margins of either 2 cm (n = 476) or 5 cm (n = 513).[3][Level of evidence A1] With a median follow-up of 11 years, there was no statistically significant difference in OS between the two treatment groups

Hypoactive Sexual Desire Disorder is defined as a persistent or recurrent absence of sexual desire that causes personal distress and is not better explained by another medical condition, medication, or situational factor

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Understanding Long-Term Use and Sustainability Patients considering this treatment option should discuss with their healthcare provider the potential risks and benefits associated with prolonged use, as well as strategies for maintaining weight loss results once the medication is discontinued