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Additionally, the lipid matrix of LDs served as an oxidation substrate for ROS, exacerbating lipotoxicity, perturbing metabolic balance, and triggering apoptosis in cancer cells

Moreover, HO-1 knockout experiments have revealed a preventive role of the Nrf2/HO-1 axis in inflammation

Examples include ibuprofen, naproxen, and aspirin

Glutathione is an essential antioxidant in the cells that prevents damage of biomolecules due to oxidation

However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC