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Summary of molecular imaging studies in late-life depression With respect to neurotransmitter deficits in LLD, pre-synaptic serotonergic deficits are observed, especially in cortical and limbic regions, while post-synaptic receptors (5-HT1A, 5-HT2A, 5-HT4) are affected to a limited extent, in contrast to MCI, AD and PD that show more widespread pre and post- synaptic serotonin deficits

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GLP-1R is present in the human choroid plexus, where GLP-1R analogs reduces cerebrospinal fluid secretion and intracranial pressure by increasing the intracellular concentration of cyclic adenosine monophosphate and inhibiting the Na + /K + ATPase pump in the choroid plexus [25]