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Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice

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[DOI] [PubMed] [Google Scholar] 4.Illippangama A.U., Jayasena D.D., Jo C., Mudannayake D.C

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Failures to submit INDs and gaps in clinical controls were part of this years citations

Each incretin receptor agonist effects on body weight and energy metabolism may be slightly different and, in the case of dual and triple agonists, frequently complementary