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Incretin Plus Metformin and Sulfonylurea Although several studies have evaluated the use of incretin therapy in combination with metformin and a sulfonylurea, there have been no such head-to-head comparisons

These medications can cause weight gain, depression, bloating, and irregular bleeding, as well as increase cardiovascular risk (Laufer 2003)

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Recommended dose: 1 sachet per day during one of the three meals of the day

Eli Lilly's Twincretin Design Eli Lilly's research team, led by scientists including Tamer Coskun and Matthew Emmerson, pursued a "twincretin" strategy: engineering a single peptide molecule that activates both GIP and GLP-1 receptors