A fasting morning ferritin level below 75 ng/mL (with consideration of C-reactive protein, as ferritin is an acute phase reactant) may warrant iron supplementation even in the absence of anemia, as brain iron stores may be depleted despite normal peripheral iron indices
For most patients, the GI effects are more manageable than cardiovascular stress, but individual tolerance varies
Plasma semaglutide concentrations were similar in dogs undergoing pyloric ligation (to prevent intestinal absorption) compared to non-ligated dogs, with plasma concentrations in the splenic vein being significantly higher than in the portal vein, providing further evidence that the stomach is the site of absorption
Changes in liver enzymes
At 5 mg/mL, it is 1.0 mg
49 In another phase 1 study conducted in 37 Japanese patients, the most common treatment-related side effects were nausea, vomiting, abdominal discomfort, diarrhea, and headache, mostly mild to moderate in severity