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Arginase 1based immune modulatory vaccines induce anticancer immunity and synergize with AntiPD-1 checkpoint blockadeARG1 vaccines induce antitumor immunity in combo with antiPD-1

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instead, it becomes a chronic, self-perpetuating cycle

In contrast, under antioxidant/low-ROS conditions (such as in certain tumor microenvironments or after treatment with BPC157 in our study), BACH1 becomes stabilized and can switch to promoting angiogenesis by directly activating target genes like VEGF

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