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In particular, the documentation of multiple IFs and aggregate collection factors (IFD-1/IF, IFD-2/IF, FTT-2/14-3-3, HSP-1/Hsc70) localized to the same soma compartment with shared functional capacity to modulate exopher extrusion levels support an unanticipated intersection between aggresome-like organelle formation and exopher extrusion

The cells were exposed for various times, after which the media was removed and the cells were washed with warm PBS and lysed by brief sonication in fresh PBS

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Intriguingly, in an organotypic 3D tissue culture model, mTORC1 supports the expression of aminotransferases and the suppression of GDH in proliferating cells [96]

Agents that cause depletion of catecholamines from the sympathetic nerve terminals (e.g., reserpine) can also antagonize indirectly acting agents (such as tyramine) because there is a lack of catecholamines to be released