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This assay reflects the combined activity of multiple proteasome species, including 20S, 26S, and immunoproteasome complexes, rather than selectively measuring 26S activity

Life Sci 140:5763

But the consequences of using a suboptimal topical are generally limited to skin irritation and wasted money rather than systemic harm

Likewise, our results demonstrating increased in vivo FAO in G49-treated DIO mice extend previous data of Boland et al

Importantly, no unusual biphasic response was seen (unlike zinc, which showed stimulation at very low doses before inhibiting at higher concentrations)