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IR/IGF1R DKO brown preadipocytes were obtained as previously described (15, 40)

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The mices body weight, as well as food and water intake, were also recorded weekly, while (HbA1c) levels in tail vein blood were assessed at the beginning and end of the experiment [1]

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Two-way ANOVA detected significance in the main effect of exposure (home cage vs novel environment, p = 5.8 10 9 , F (1,31) = 63.087) and genotype ( p = 9.3 10 13 , F (1,31) = 133.291) and interaction between them ( p = 0.0017, F (1,31) = 11.797)