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Packing list: 2 x Glp-1 drop

Colchicine, para-aminosalicylic acid and heavy alcohol intake for longer than two weeks may produce malabsorption of Vitamin B12

Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits

doi: 10.1016/S2468-1253(17)30285-6

4.2 Future directions Future research should focus on confirming these findings in randomized controlled trials (RCTs) to establish causality and evaluate the effectiveness of GLP-1 RAs as therapeutic agents for SUDs