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Cantarelli, C., Leventhal, J

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Namenda does appear to slow the progression of disease symptoms in some patients, particularly when given in combination with acetylcholinesterase inhibitors [45,46], but does not impact the underlying neuropathology of this disease

The clinical significance of this slight difference is debatable, but the effect is mentioned here as a possible off-target effect of DPP-4 inhibitors

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Clinical data[ 6] show that these effects are typically mild to moderate and tend to diminish with continued treatment