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Unlike the current widely used medications such as Ozempic and Mounjaro that target the GLP-1 pathway alone, retatrutide, known as a GLP-3, targets three pathways related to metabolism: GIP, GLP-1, and glucagon

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GLP-1R is expressed in the pancreas, gastrointestinal tract, heart, lungs, kidneys, and brain, and the localization of these receptors determines GLP-1RAs effects [89]

Understanding these cardiovascular effects is essential for safe prescribing and monitoring, particularly in patients with baseline hypotension or those taking antihypertensive medications

During perimenopause, estrogen levels don't decline steadily

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