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Hair pigmentation is regulated by melanogenesis within the follicle and modulated by various factors, including melanocyte-stimulating hormone (MSH), adrenocorticotropic hormone (ACTH), endothelin-1, prostaglandins, leukotrienes, fibroblast growth factors, nitric oxide, catecholamines, as well as essential vitamins and minerals

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doi:10.1001/jama.2020.16909 Rist PM, Buring JE, Cook NR, Manson JE, Rexrode KM