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Bhaskar et al., NPY expression was reduced in the frontal and motor cortices of chronic alcohol drinkers relative to controls (Mayfield et al., 2002)

Challenges are almost certainly to come

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Research indicates that GIP co-activation may actually reduce some GLP-1 related side effects, particularly nausea, while enhancing overall weight loss

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Nkhoma DE, Jenya Soko C, Joseph Banda K, Greenfield D, Li YCJ, Iqbal U (2021) Impact of DSMES app interventions on medication adherence in type 2 diabetes mellitus: systematic review and meta-analysis