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While FOXO4 can influence mitochondrial function indirectly through its regulatory effects on cellular processes, it does not directly target mitochondria like the other mitochondria-targeted peptides listed above

To gauge improvement, track specific issues you had before, for instance, frequency of mouth sores (which can occur with B deficiencies), or numbness in feet, or level of fatigue on a 10-point scale

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While not every child responds the same way to supplementation, the research shows that a trial of methyl B12 may be worth consideration.