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However, the process of making ATP also produces reactive oxygen species (ROS), such as hydrogen peroxide, which can damage the cell at higher levels

While most people produce enough L carnitine naturally, certain groups may benefit from supplementation: Vegans and Vegetarians: Since the primary dietary sources are meat and dairy, those on plant-based diets often have lower levels and may benefit from supplements

Neuromuscular disease Myopathy can be seen with biochemically defined defects in mitochondrial substrate transport or utilization, including the myopathic form of carnitine deficiency

Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma

Carnitine for Kidney Disease and Hemodialysis Given that the kidney is a major site of carnitine production, damage to this organ can cause a significant carnitine deficiency

Aquaculture 249 , 439447 (2005)