This process is affectionately called "replicate the myth, then duplicate the results" usually at a point so far beyond the normal parameters that it isn't even remotely plausible that it happened by accident or, at the very least, so incredibly dangerous that anyone capable of sound judgment wouldn't attempt it in the first place
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These were mainly associated with THC products and arose spontaneously and rapidly in young, healthy individuals
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Because, as Dr Yach says above, smoking tobacco kills and nicotine doesnt