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However, the risk of respiratory illness and death has been reported to be increased in infants of low birth weight for gestational age as well as diminished airway function

European prosecutors, working in close coordination with Italian law enforcement authorities, have dismantled a large-scale illegal cigarette manufacturing operation in Italy, dealing a significant blow to organized crime networks involved in tobacco smuggling across the European Union

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1986a IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans

It sounds like it should have a simple answer but the honest truth is theres no single magic number