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Larger particles favor the larger and more central airways, while smaller particles are deposited in the smaller peripheral airways and sacs, leading to chronic inflammation, infections, oxidative stress and damage to the airways and gas exchange areas of the lung [15]

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However, compared to cigarette mainstream smoke TSNA levels were reduced by about 8090% (33, 34)

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In addition, the thermal decomposition of PG and VG is linked to the creation of several harmful chemical compounds, including acetone, acrolein, formaldehyde, acetaldehyde, and benzaldehyde [38]