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1 Bupropion is contraindicated in patients: 15 During acute alcohol or benzodiazepine withdrawal With a central nervous system tumour With a history of seizures, eating disorders (including bulimia or anorexia nervosa) or bipolar disorder

Furthermore the industry wanted to know if smoking was implicated in disease, was it due to some specific agent or agents in the tobacco which could be removed from the smoke. 2

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