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Acknowledgements We thank Chris Bader, Ed Day, Pete Simi, Karen Snedker, and Robert Wagmiller for their comments on an earlier version of the manuscript

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Bupropion hydrochloride tablets are contraindicated in patients with a seizure disorder, current or prior diagnosis of anorexia nervosa or bulimia, or undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs [see Contraindications (4), Drug Interactions (7.3)]