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According to Anam A.s 2025 study, Smoking negatively impacts ocular surface health and corneal nerve metrics., Smokers exhibit 18.8% prevalence of neuromas compared to only 4.2% in non-smokers, with significantly larger neuroma size and total area

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Over time, the tobacco market has become more global (Jha and Chaloupka 2000) due to loosened trade restrictions, rising incomes in many countries, and aggressive marketing by tobacco companies