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Ethics declarations Ethical Approval and Consent to Participate This study is part of a programme of research originally approved by the Northern Region Ethics Committee in 2003 (AKY/03/12/314), with subsequent approval by the National Multi Region Ethics Committee in 2007 (MEC07/19/EXP) and with annual re-approval since as part of a research programme (2024 EXP18564)
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4547 However, because these studies specifically excluded patients with severe, underlying cardiac diseases, the clinical practice guideline 37 recommends that because of a lack of safety data in these higher-risk populations, NRT should be used with caution among patients who have experienced a myocardial infarction within the past two weeks and among those with serious arrhythmias or unstable angina
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