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Tobacco smoking is heavily associated with respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, asthma, and lung cancer

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In this regard, a reduction in HR could serve as a marker of decreased sympathetic activity 23

It took decades to prove that cigarette smoking causes cancer, heart disease, and early death

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On the other hand, there are questions around whether there is even sound scientific evidence to support the notion that reducing nicotine levels in cigarettes would actually reduce population risk, Azer wrote