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It's why the nicotine addict reaches for nicotine instead of a jack when their tire goes flat

When this ad made its rounds on social media, theories were bandied about to explain just what went wrong in this ad

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The unmethylated CpG motifs are recognized by toll-like receptor 9 (TLR9), an endosomal receptor that signals through MyD88 to induce NF-B activation

But there are annual cleanups and a Great Lakes-wide effort is coming up