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It is critical to personalize, adjust, and manage these prescriptions, as with any medical treatment, considering external (exercise variables) and internal (acute response to exercise) factors influenced by personal, genetic, functional, psychosocial, and environmental factors [95] (see Fig

Immunomodulatory Effects of Nicotine on Microglia Nicotine induces both immunosuppressive and immuno-stimulatory effects in the CNS (126, 127)

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