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Thats where I see the biggest change increasingly so, mainstream media is becoming comfortable again with communicating the sex appeal of cigarettes. Lets be honest, Oviatt said, a photo of someone smoking a cigarette on Instagram is going to land a lot better than one of them holding a neon vape you can play Brick Breaker on. He believes smoking has become cultural shorthand

Ethics declarations Conflict of interest The authors have no conflicts of interest to disclose

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Among these, DNA methylation is the most extensively studied epigenetic mechanism in the male germline, crucial for regulating the plasticity of spermatogonial stem cells (SSCs)

25 No application has yet been made to the TGA for approval of nicotine-containing e-cigarettes for therapeutic use in Australia