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When guys are trying to affect a lower voice that nature didn't intend for them, they tighten up and push it out, and there's just a lot of muscle tension in and around the throat, Sherwood says

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The results are concerning given that the study tested only the effects of half an hour of smoking, whereas most people smoke hookahs for several hours

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164 This approach uses genetic polymorphisms that have been previously shown to be robustly associated with one of the exposures of interest