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While chronic infections with HBV and HCV, heavy alcohol consumption, and diabetes are well-established primary risk factors for HCC, there is compelling and growing evidence that prolonged and active cigarette smoking is an independent and significant risk factor for its development [98, 99]

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OMB estimates that, should the HIP-HMO rate increase apply to GHI-CBP/NYCE PPO enrollees, health insurance costs could increase by a total expense of $527 million in FY 2026, growing to $612 million in FY 2029

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