When choosing a commercial space, you may want to follow these rules of thumb: Central location accessible via public transport Ventilated and spacious, with good natural light Flexible lease that can be extended as your business grows Ready-to-use space with no major renovations or repairs needed 3
Epidemiology Peak onset: 1535 years Slight female predominance Higher prevalence in smokers Etiology & Pathogenesis Multifactorial: genetic susceptibility (NOD2), immune dysregulation, environmental triggers Transmural inflammation fistulas, strictures, abscesses Discontinuous involvement (skip areas) Common Sites Terminal ileum (most common) Ileocolonic Colonic Perianal disease common Clinical Features Intestinal: Chronic diarrhea (often non-bloody) Abdominal pain (classically RLQ) Weight loss Malabsorption Intestinal obstruction (strictures) Perianal disease: Fistulas Abscesses Anal fissures Extra-intestinal Manifestations Joints: Peripheral arthritis, ankylosing spondylitis Skin: Erythema nodosum Eyes: Uveitis, episcleritis Hepatobiliary: Fatty liver, gallstones Renal: Oxalate stones Diagnosis Ileocolonoscopy with biopsy gold standard Cobblestone mucosa, aphthous ulcers, skip lesions Histology: Non-caseating granulomas (not always present) Imaging: MR enterography / CT enterography for extent & complications Labs: CRP/ESR, anemia, hypoalbuminemia Exclude infection Management Induction of remission: Corticosteroids (moderatesevere) Budesonide (ileocecal disease) Maintenance: Azathioprine / Methotrexate Biologics: Anti-TNF (infliximab), anti-integrin, anti-IL-12/23 Surgery: For complications (strictures, fistulas, abscesses) Not curative disease often recurs Complications Strictures obstruction Fistulas (entero-enteric, entero-vesical, perianal) Abscesses Malnutrition Increased risk of colorectal cancer Transmural inflammation Skip lesions Any part of GI tract Smoking worsens disease Surgery cure To view or add a comment, sign in Esophageal Cancer Definition: Malignant tumor of the esophagus, the muscular tube connecting the pharynx to the stomach
Her new film, Love Sounds , is forthcoming in 2017
Prevent student attending SUNY Cortland from being targeted by any marketing, promotion, or distribution of tobacco, nicotine or electronic cigarette/electronic aerosol delivery device products on campus
Geographic Tongu e - It's mostly harmless, but geographic tongue can make multiple, smooth patches appear on the tongue, making it look a little like a map
Especially in the bridge at the end, that's a true story
