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For individuals smoking two packs or more daily, the risk rises dramatically, reaching 15 to 30 times higher

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This led to the cancellation of the 2025 National Youth Tobacco Survey, whose results were highly anticipated to see if anecdotal evidence of increased nicotine use would show up in the official data

Those who are non-smokers can recognize a smoker almost immediately

Abbreviations BC: breast cancer TAM: tumor-associated macrophages CCL5: C-C motif chemokine ligand 5 CCR1/3: chemokine receptor 1/3 VCAM-1: vascular cell adhesion molecule 1 E-cig: E-cigarettes CS: cigarette smoking MMPs: matrix metalloproteinases VEGF: vascular endothelial growth factor TNF: tumor necrosis factor EVC: E-cigarette vapor condesate Declarations Acknowledgement None