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Tumours in never-smokers also tend to carry a distinctive set of genetic changes called driver mutations that are involved in turning cells malignant

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What the paper describes in sections that concern body responses rather than detection of chemicals are primarily various effects of nicotine, and frequently of nicotine overdose

It also differs from regular tobacco in that it is steam cured rather than flue cured

Smokeless tobacco users may need to see their dentist more often to make sure a problem doesn't develop

Mucous membranes often lose elasticity and become fibrous