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In any of the non-purified CBD products that have therapeutic utility, it is difficult to tell whether the benefit of the product arises from CBD as the active pharmaceutic ingredient (API), or as a consequence of the other chemicals present, or as a consequence of any interaction (pharmacodynamic or pharmacokinetic) between the compounds (referred to as the entourage hypothesis)

However, certain flavour profiles cant exist without specific compounds that may trigger sensitivities

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