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doi:10.4103/ijpvm.IJPVM_85_18

A custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse A Counterblaste to Tobacco Written by King James I of England in 1604, A Counterblaste to Tobacco is one of the earliest diatribes against smoking

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List of cigarette smoke carcinogens Commercial tobacco smoke is a mixture of more than 5,000 chemicals