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The induction of stemness in lung cancer, associated with e-cigarette use, was mediated through upregulation of a stemness marker SRY (sex determining region Y)-box 2 ( Sox2) , a gene that is highly expressed in stem cells and responsible for self-renewal along with the Yes associated protein 1/ E2F transcription factor 1/Octamer-binding transcription factor 4 ( Yap1 /E2F1/ Oct4) signaling axis [26]

[Update: the Australian government has issued a reaction to the decision, available here.] The large decision document shows the extensive analysis and effort on all sides in this years-long case

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Hence, smoking causes early death and productivity loss, inducing serious socioeconomic damage worldwide, which was estimated to be over 422 billion US$ 9