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One of the most important factors influencing burn rate, draw, and enjoyment is the moisture level of the tobacco

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It is the one that allows steady receptor adaptation without triggering compensatory behavior

It is worth pointing out that you would have to consume in the region of two-and-a-half to three 2ml refills of 20mg/ml e-liquid in a short amount of time to begin to reach dangerous levels (2) - and you are likely to start feeling sick before being able to consume that amount, which is likely to stop you vaping long before you are at serious risk