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It is told in this manner: "Tarlton as other gentlemen used, at the first coming up of tobacco, did take it more for fashion's sake than otherwise, and being in a roome, sat betweene two men overcome with wine, and they never seeing the like, wondered at it, and seeing the vapour come out of Tarlton's nose, cryed out, 'Fire, fire!' and threw a cup of wine in Tarlton's face

But it doesnt correlate with potency, flavor, or overall quality

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It also increases the risk of cancer occurring in esophagus, blood cells, liver, stomach, kidney, pancreas, mucinous ovary, ureter, cervix, colon, bladder, mouth, nose, throat, and voice box