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Histopathological evaluation was conducted by blinded pathologists, who assigned scores on the basis of established parameters, including inflammatory cell infiltration, tissue destruction, crypt architectural distortion, and regenerative responses

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13 Conversely, the Epidemiology of Diabetes Interventions and Complications Trial, which followed participants of the Diabetes Control and Complication Trial, demonstrated that intensive insulin therapy improved the prognosis of patients with type I DM and showed that 93 of 1105 type I DM patients presented microalbuminuria onset during the 8-year observational period