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Second, barely one year after the Deeming Rule became final, FDA substantially deregulated e-cigarettes by issuing a Guidance purporting to suspend premarket review of e-cigarettes that were on the market as of the effective date of the Deeming Rule by extending the deadline for filing PMTAs for four years (until August 2022)

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CRS was also employed as the control behavioral strategy in a randomized controlled trial (RCT) evaluating pharmacogenetic guided therapy versus varenicline 6