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daily [19], levels of nicotine dependence [38], the heaviness of smoking [39], or cumulative pack years [6], and biomarkers such as cotinine levels [40], suggesting a pharmacologic or neurobiological link between nicotine exposure and mood dysregulation

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8 While e-cigarettes can generally be a lower-risk alternative for adults who smoke cigarettes, e-cigarette use is not risk-free

Additionally, researchers still need to determine whether the medication directly reduces cardiovascular events