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Heavy smokers and ex smokers often find cigalikes helpful for quitting smoking because they feel like a real cigarette, making the transition smoother and more familiar

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Moreover, SMG secretory cells produce a MUC5B -dominated mucus that requires less post-translational processing and glycosylation than surface epithelial mucus production, consistent with recent studies finding that mucus produced from the SMGs has distinct physical properties from that of surface epithelia 36,37

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Modern smoking tobacco ( Nicotiana tabacum ) was domesticated in the precontact Andes and diffused to North America, where colonizing Europeans took up the habit of smoking after encountering Native Americans who used the plant recreationally and ceremonially