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6 The prevalence of non-functional and deletion CYP2A6 alleles in Asian populations, among whom the reported lung cancer risk for smokers is much lower than it is for Whites, has led to the hypothesis that lower levels of CYP2A6-catalyzed nicotine metabolism (resulting in the presence of more nicotine) causes decreased smoking dose and intensity and therefore decreased carcinogen exposure and lung cancer risk

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All REB-approved documents are version controlled and stored in the investigator study binder (ISB) with a corresponding log of amendments

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