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'Brazil is the largest country to have adopted an anti-tobacco law,' activist Patricia Sosa, in charge of Latin American programmes for the Campaign for Tobacco-Free Kids, told IPS

it compromises the responses of the bronchial epithelium by modifying the expression and activation of innate immunity receptors and determines the destruction of desmosomes and tight junctions with increased permeability to allergens, pollutants, and infectious agents and the release of inflammatory mediators (IL-8, IL-1, sICAM-1) 15

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A similar curve was seen for CPD, with the risk increasing sharply up to about 20 CPD before the curve began to level off