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Physical examination revealed a painful ulcerated plaque on the upper lip, a macular rash with three crater-like scarred painless lesions (considered to be healing chancres) on the glans, a nonpruritic hyperkeratotic maculopapular palmar rash and bilateral submandibular lymphadenopathy

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy