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NRT monotherapy is modestly effective, increasing 612-month quit rates by 6% when compared with placebo

There was no evidence of a carcinogenic effect in mice administered varenicline by oral gavage for 2 years at doses up to 20 mg/kg/day (47 times the maximum recommended human daily (MRHD) exposure based on AUC)

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Schlessinger states that it is hard to tell the long term effects on the skin, from an e-cig, because it is such new technology but because there are similar chemicals, he believes that it is likely that it will do the same amount of damage to the skin over time

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