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An overview of the study design is detailed in Fig
Physical addiction : It creates a strong dependence on the substance altering brain chemistry
It is primarily caused by poor oral hygiene and the buildup of plaque and tartar on the teeth
Tob Regul Sci 2019 Nov;5(6):491-501 Why flavored vape products may be attractive: green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function
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