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Building on previous discoveries, recent research has revealed that exogenous factorsparticularly cigarette smoke exposurecan fundamentally remodel this dynamically balanced architecture via nicotine-mediated epigenetic pathways (Table 3)

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However, headaches are one possible side effect of nicotine replacement therapy

In 2014, the Surgeon General's Report stated: "Death and disease from tobacco use in the United States is overwhelmingly caused by cigarettes and other burned tobacco products

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