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To clarify the effectiveness of tobacco weight reduction through decreased circumference on yields of individual sidestream smoke constituents, three 1-mg ISO tar yield ECs (K111, D111 and S111) were manufactured that differed in circumference, but maintained the same 1-mg ISO tar yield, tobacco blend and cigarette design (other than changes in filter pressure drop and paper permeability necessary to achieve the same ISO tar yield across the three cigarettes

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Effect on Diflucan Effectiveness Some data reports that alcohol may reduce the effectiveness of Diflucan and other medications