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This interaction is mediated by an impact of smoking on clearance

+ A standard 20-cigarette pack delivers 160-240 puffs total, depending on smoking technique

Upregulation of ACE-2 in smokers could be a protective mechanism to prevent lung damage in smokers

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Precaution: Conduct patch test before regular use If skin irritation occurs: Gently wash with mild soap, apply cool compress Discontinue use and seek medical help if dizziness/nausea occurs